In Antony and Cleopatra, the Mediterranean Sea plays a particularly vital role. Changeable, slippery, and unfathomable, it stands out as the perfect element to give shape to what has been defined as the play's `sense of instability', which dominates both its more explicitly political dimension and the intricate, personal dynamics between the two eponymous characters. This volume offers fresh insights into the Mediterranean dimension of Antony and Cleopatra, exploring issues as varied as performance and self-representation, motherhood, and statecraft, as well as the ways in which contemporary digital tools can contribute to underscoring the play's enduring relevance.