This book delves into the transformative impact of generative AI in the context of modern industrial settings, focusing specifically on the subtle distinction between original equipment manufacturers (OEMs) and process industries. Each industry faces unique challenges and oportunities in the era of Industry 4.0 and 5.0, further complicated by the rapid development and integration of emerging technologies. The narrative begins with a fundamental exploration of the business models and strategic nuances that define OEMs and process industries. It provides an in-depht examination of how these industries can leverage generative AI and other advanced technologies to optimize production, enhance innovation, and ultimately redefine market dynamics. The book explores the concept of "Human in the Loop" and formalizes the concept of "Human at the Edge", emphasizing the indispensable role of human oversight in AI-based systems. This discussion is framed in the broader transition from human-machine interface (HMI) to human-computer interaction (HCI), highlighting the shift toward more interactive and reciprocal frameworks in industrial applications.