In the current highly complex business environment, there exist challenging objectives attainable only through collaborative efforts involving multiple individuals. Therefore, the relationship stands as the dividing line between success and failure in any activity undertaken by entrepreneurs, managers, or professionals.In order to build long-lasting relationships, it is necessary to switch from Effective Communication, which can be instinctive, self-centred, and can be prone to cognitive biases, to Strategic Communication. The latter, through the application of the O.D.I. Method®, allows to enhance all the elements involved (I, You, and Context) and guards against the effects of cognitive reasoning errors, bias, and noise.This manual blends communication, psychology and neuroscience studies from the classical and more recent tradition with the analysis of concrete business cases: the result is a multidisciplinary approach that gives the communicator a wide range of skills to draw on.