"Reinventing University. The Digital Challenge In Higher Education" is a collection of papers which navigates the multifaceted intersections between technology and higher education, offering a timely exploration of the challenges and opportunities that define the contemporary academic landscape. The digital challenge in higher education is not merely a technological shift; it is a transformative force that is reshaping the very essence of academic practices. As we stand at the confluence of tradition and innovation, this special issue serves as a repository of insights, ideas, and innovations, each carefully curated by the D-ChallengHE Scientific Board. These contributions delve into the complexities of reinventing universities in the digital age, addressing the critical themes that resonate across the academic spectrum.