This publication is based on selected interventions from a cycle of seminars titled: "The Organization for Security and Co-operation in Europe (OSCE) as a model for multilateral regional diplomacy of the 21st century", organised in 2022 by the Permanent Mission of Italy to the OSCE with some Italian Universities. The initiative took place from March to May 2022 in virtual format, with the aim to promote the knowledge and the study of the role and activities of the OSCE and to strengthen cooperation between diplomacy and the Italian university system. All the lectures were given by diplomats of the Permanent Mission and the Ministry of Foreign Affairs and International Cooperation, by Italian officials serving at the OSCE and by university professors and experts of the Organization. Around 60 university students from nine Italian universities took part.