How and at what levels does the cultural heritage produce well-being in the present? What actions and methodologies can be put in place to trigger practices of active involvement? Which collaborations make it possible to overcome systemic obstacles? Which tools are best suited to evaluate efficiency and effectiveness? In the wake of the studies on the binomial 'cultural heritage-well/being', the 2021 CHAIN (Cultural Heritage Academic Interdisciplinary Network, established by the PhD in Sciences of Cultural Heritage and Production of the University of Catania) team edited this volume, which collects the contributions of the conference held in 2021, triggered by the outbreak of the crisis of COVID-19. The papers published here are arranged according to three thematic sessions, i.e. 'Memory', 'Perception', and 'Research-Actions'.