Drawing on a broad theoretical framework, embracing the History of the Book, Text Technologies and Digital Humanities in their intersections with Shakespeare Textual Studies, this volume examines how medium-specific forms of textual transmission and editorial mediation shape the reader's possibilities of understanding and engaging with the playwright's works, with important hermeneutic implications. Considering a wide range of case studies, the volume shows how digital media go far beyond reconceptualising print-based ways of accessing, visualising and studying Shakespeare. Indeed, by defamiliarising and 'remediating' the rhetoric of the mise en page in increasingly interactive environments, digital media also enhance our awareness of how print-inflected categories have impinged on our understanding of Shakespeare and early modern drama for more than four centuries.