The study was developed as part of the INLEARN project, co-founded by the Know-how Exchange Programme of the Central European Initiative. The purpose of the study is to provide Higher Education Institutions and practitioners, policy makers, and education funders in non-EU CEI Member States with design principles and effective implementation models for online and blended courses and programmes, based on widely accepted learning theories, available evidence from research, and best practice. Part 1 provides a conceptual framework for describing the variety of phenomena that go under the umbrella term of e-learning. Part 2 focuses on current trends and future prospects for e-learning in the European Higher Education Area. Part 3 gives insights into teaching and learning activities, people & roles, and technology in e-learning. Finally, relevant instructional and multimedia design principles are presented, as well as valuable guidelines for course development, implementation, and evaluation.